Sphingosine-1-phosphate (S1P) acts on a set of G protein-coupled receptors in the plasma membrane and also as a second messenger in certain cell types. There are two possible pathways to mobilize intracellular Ca2+ concentration by S1P. One is through phospholipase C. and the other is through intracellular Ca2+ channels operated by S1P. https://www.spidertattooz.com/CND-Shellac-Be-Demure-0-5oz-p13568/