Ribonuclease H2 (RNase H2) exhibits both single ribonucleotide excision activity (activity A) and RNA strand degrading activity (activity B). Val143 of human RNase H2 is located at the active site and is conserved in eukaryotic RNase H2. In this study. we explored the role of Val143 in catalytic activity and substrate specificity. https://www.roneverhart.com/Whirlwind-Direct-2-Direct-Box-p14308/